Anti-programmed cell death protein-1/ligand-1 therapy in different cancers
نویسندگان
چکیده
منابع مشابه
Programmed death protein 1 inhibitors making inroads in multiple cancers.
In a new study, patients with untreated metastatic melanoma who took nivolumab, a programmed death protein 1 (PD-1) inhibitor immunotherapy, had an overall survival rate of 72.9%, compared with 42.1% for those who took the standard-of-care chemotherapy, dacarbazine. In the 418-patient phase III median progression-free survival was 5.1 months and 2.2 months, respectively. Of these patients—none ...
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Background: Programmed cell death protein-1 (PD-1)/PD-L1 pathway is one of the immune checkpoint pathways involved in regulation of the immune responses and suppression of anti-tumor defense. PD-1/B7-H1-blocking antibodies improve immune responses such as cytotoxic activity of CD8+/CD4+T cells and also increase mortality of tumor cells; however their use is accompanied by adverse effects in pat...
متن کاملFulminant type 1 diabetes mellitus with anti‐programmed cell death‐1 therapy
Anti-programmed cell death-1 (PD-1) antibodies are regarded as a risk factor for insulin-dependent diabetes mellitus as a side-effect. While a small number of cases have been reported, evidence remains limited. This is the first report of an Asian patient developing insulin-dependent diabetes during anti-PD-1 therapy. A 55-year-old euglycemic woman receiving nivolumab for malignant melanoma sho...
متن کاملDiverse cutaneous adverse eruptions caused by anti-programmed cell death-1 (PD-1) and anti-programmed cell death ligand-1 (PD-L1) immunotherapies: clinical features and management
Background The anti-programmed cell death-1 (PD-1) and anti-programmed cell death ligand-1 (PD-L1) immunotherapies have shown exceptional activity in many cancers. However, these immunotherapies can also result in diverse adverse cutaneous eruptions that need to be better characterized for ongoing management. The objective was to provide clinical and histopathologic descriptions of the variety ...
متن کاملIntrinsic insulin secretion capacity might be preserved by discontinuing anti‐programmed cell death protein 1 antibody treatment in ‘anti‐programmed cell death protein 1 antibody‐induced’ fulminant type 1 diabetes
Intrinsic insulin secretion capacity may be preserved by discontinuing anti-PD-1 antibody treatment in 'anti-PD-1 antibody-induced'fulminant type 1 diabetes.
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2015
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2015.124